Potential Applications
Cordlife's Exclusive: Epithelial stem cells (EpSCs)
Disorders investigated in MSC Clinical Trials
- Tissue repair
- Stroke
- Heart failure
- Alzheimer’s disease
- Parkinson’s disease
- Spinal cord injury
- Orthopaedic indications (bone, cartilage, tendon repair)
- Liver failure
- Immune modulation or reconstitution
- HIV
- Type 1 diabetes
- Graft versus host disease (GvHD)
- HSCs engraftment support
- Shorten time of engraftment
Reduce immune system complications
- Shorten time of engraftment
Disorders investigated in EpSC Clinical Trials
- Soft tissue repair
- Skin wounds
- Ocular surface disorders
- Persistent epithelial defect
- Replacement of insulin-producing cells for diabetic patients
- Haemophilia
Today, more than 300 clinical trials1 are ongoing worldwide to uncover the potential of MSCs. Thus far, encouraging results have been published; stem cell treatments have been proven safe and capable of repairing damage caused by stroke and heart disease. MSCs have also been used in combination with HSCs as a dual therapy to promote faster engraftment of HSCs and to reduce immune system complications2.
EpSC Clinical Trials – Global Institutions
| Diseases | Name of Universities/Research Institutions |
|---|---|
| Skin wound | Singapore General Hospital Burn Centre |
| Ocular surface disorders | Singapore Eye Research Institute Kyoto Prefectural University of Medicine, Japan |
| Persistent epithelial defect | National Eye Institute, Hanoi, Vietnam |
MSC Clinical Trials – Global Institutions
| Diseases | Name of Universities/Research Institutions |
|---|---|
| Stroke | University Hospital, Grenoble, France |
| Spinal Cord Injury | Chinese University of Hong Kong Cairo University, Egypt |
| Multiple Sclerosis | Spain-Carlos Health Institute University of Cambridge, United Kingdom Cleveland Clinic, United States |
| Amyotrophic Lateral Sclerosis | Hadassah Medical Organization, Israel |
| Parkinson‘s Disease | Jaslok Hospital and Research Centre, India |
| Multiple System Atrophy | Yonsei University, South Korea |
| Liver Disease | Cytori Therapeutics, United States |
| Diabetic Foot Ulcer | Third Military Medical University, China Washington DC Veterans Medical Centre, United States Ruhr-University Bochum, Germany |
| Diabetes | Fuzhou General Hospital, China Uppsala University, Sweden |
Sources:
- ClinicalTrials.gov. Accessed in October 2013.
- Battiwalla M, Hematti P. 2010. Cytotherapy. 1 January 2010.
QR 8.1-7-3-a DCR 800